• CLIA-Waived Syphilis Point-of-Care Testing Options for Providers (PDF)​
  
• Evaluating Patients for Primary Syphilis (PDF)
  
• Evaluating Patients for Secondary Syphilis (PDF)
  
• Emergency Department Screening & Treatment for Syphilis ​
  
• California Department of Public Health (CDPH) Updates Syphilis Screening Recommendations​
  
• CDC Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for B​acterial Sexually Transmitted Infection Prevention, United States, 2024
• CDPH Dear Colleague Letter - Doxycycline Post-Exposure Prophylaxis (doxy PEP) for the Prevention of Bacterial Sexually Transmitted Infections (STIs) (PDF)​​
  
• Considerations for the Implementation of Point of Care Tests for Syphilis (PDF) (hhs.gov)
• Clinical Interpretation of Syphilis Screening Algorithms (PDF)(californiaptc.com)
• FAQ Regarding Reverse Screening Algorithm (PDF)​​
  
• Pregnancy and Substance Use: A Harm Reduction Toolkit​​​​
  
• Syphilis Treatment Intervals in Non-Pregnant Patients: A Clinical Resource for Providers (PDF)
  
• CDPH Dear Colleague Letter - Opt-Out ED Screening for HIV, HCV, and Syphilis (3/28/22) (PDF)
  
• CDPH Dear Colleague Letter - Call to Expand HIV and Syphilis Testing for Pregnant Women (11/16/21) (PDF)
  
• Health Alert: Increasing Cases of Congenital Syphilis and Syphilis Among Females in Northern California (Oct. 2021) (PDF)
  
• Screening for Syphilis in Emergency Departments Implementation Guide​
  
• Rapid Syphilis Testing Fact Sheet & FAQs (PDF)
  
• Syphilis Treatment Guidelines, 2021 (CDC)
  
• Neurosyphilis Guide (PDF)
• Use of Treponemal Immunoassays for the Screening and Diagnosis of Syphilis: Guidance for Medical Providers and Laboratories in California (PDF)**

**Please note, the STI treatment guidelines referenced in this document are out of date. Please refer to the 2021 STI Treatment guidelines for the current treatment regimens.​​​​

• A Prenatal Care Model for Congenital Syphilis Prevention: The Pregnancy Connections Clinic Guide (PDF)​
• Screening for Syphilis in Emergency Departments Implementation Guide​
• Syphilis Reactor Algorithm and Charts (PDF)
• CDC Division of STD Prevention
  

• CDPH Doxy PEP Webpage
• Syphilis Fact Sheet (CDC) (English)
  
• Syphilis Fact Sheet (CDC) (Spanish)
  
• Syphilis and Men Who Have Sex with Men (MSM) Fact Sheet (CDC) (English)
  
• Syphilis and Men Who Have Sex with Men (MSM) Fact Sheet (CDC) (Spanish)
  
• Free STD Retest Reminders for Patients
• STD Test Sites
• Teen-Friendly STD Information and Health Clinics
• Condom Access for Teens
• Assess Your Risk for STDs
  
• HIV PrEP Locator
  
• Doxy PEP Locator
  

• Syphilis and Gonorrhea in MSM: 2017 Snapshot (PDF)
• Syphilis in Women and Babies: 2017 Snapshot (PDF)
• Syphilis Tables (Excel)​
• Syphilis Slides (PPTX)