• CLIA-Waived Syphilis Point-of-Care Testing Options for Providers (PDF)​
  
• Evaluating Patients for Primary Syphilis (PDF)
  
• Evaluating Patients for Secondary Syphilis (PDF)
  
• Emergency Department Screening & Treatment for Syphilis ​
  
• California Department of Public Health (CDPH) Updates Syphilis Screening Recommendations​
  
• CDC Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for B​acterial Sexually Transmitted Infection Prevention, United States, 2024
• CDPH Dear Colleague Letter - Doxycycline Post-Exposure Prophylaxis (doxy PEP) for the Prevention of Bacterial Sexually Transmitted Infections (STIs) (PDF)​​
  
• Considerations for the Implementation of Point of Care Tests for Syphilis (PDF) (hhs.gov)
• Clinical Interpretation of Syphilis Screening Algorithms (PDF)(californiaptc.com)
• FAQ Regarding Reverse Screening Algorithm (PDF)​​
  
• Pregnancy and Substance Use: A Harm Reduction Toolkit​​​​
  
• Syphilis Treatment Intervals in Non-Pregnant Patients: A Clinical Resource for Providers (PDF)
  
• CDPH Dear Colleague Letter - Opt-Out ED Screening for HIV, HCV, and Syphilis (3/28/22) (PDF)
  
• CDPH Dear Colleague Letter - Call to Expand HIV and Syphilis Testing for Pregnant Women (11/16/21) (PDF)
  
• Screening for Syphilis in Emergency Departments Implementation Guide​
  
• Rapid Syphilis Testing Fact Sheet & FAQs (PDF)
  
• Syphilis Treatment Guidelines, 2021 (CDC)
  
• Neurosyphilis Guide (PDF)
• Use of Treponemal Immunoassays for the Screening and Diagnosis of Syphilis: Guidance for Medical Providers and Laboratories in California (PDF)**

**Please note, the STI treatment guidelines and syphilis screening recommendations referenced in this document are out of date. Please refer to the 2021 STI Treatment guidelines for the current treatment regimens, and California Department of Public Health (CDPH) Updates Syphilis Screening Recommendations.​

Note: Please check our archive webpage for additional Dear Colleague Letters, Health Alerts and Recommendations, and All Facility Letters.​​

• A Prenatal Care Model for Congenital Syphilis Prevention: The Pregnancy Connections Clinic Guide (PDF)​
• Screening for Syphilis in Emergency Departments Implementation Guide​
• Syphilis Reactor Algorithm and Charts (PDF)
• CDC Division of STD Prevention
  

• CDPH Doxy PEP Webpage
• Syphilis Fact Sheet (CDC) (English)
  
• Syphilis Fact Sheet (CDC) (Spanish)
  
• Syphilis and Men Who Have Sex with Men (MSM) Fact Sheet (CDC) (English)
  
• Syphilis and Men Who Have Sex with Men (MSM) Fact Sheet (CDC) (Spanish)
  
• Free STD Retest Reminders for Patients
• STD Test Sites
• Teen-Friendly STD Information and Health Clinics
• Condom Access for Teens
• Assess Your Risk for STDs
  
• HIV PrEP Locator
  
• Doxy PEP Locator
  

• Syphilis and Gonorrhea in MSM: 2017 Snapshot (PDF)
• Syphilis in Women and Babies: 2017 Snapshot (PDF)
• Syphilis Tables (Excel)​
• Syphilis Slides (PPTX)