Pre-Approval
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Not Applicable
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āSupplemental Information Requested
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Requested: Measles vaccination history, travel history, rash onset date, symptoms, if contacts to known case(s)
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āSubmittal Form
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Specimens must be accompanied with a hard copy of the completed VRDL General Purpose Specimen Submittal Formā (PDF)ā or a form generated in the VRDL Lab Web Portal.āā
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Methodology
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Real-time RT-PCR (LDT) (Diagnostic)
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Reflex Testing
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Genotyping
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āAcceptable Specimen Type(s) and Collection Method
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Human specimens:
- Respiratory specimens: Throat and/or NP swab in sterile collection tube with liquid Viral Transport Media or Universal Transport Medium
- Urine: Processed urine preferred
Respiratory swabs must be a Dacron or synthetic tip with aluminum or plastic shaft.
To process urine, centrifuge urine sample (10-50 mL) at 500-600 x g for 5ā10 min at 2-8Ā°C. Discard supernatant and resuspend cell sediment in 2ā3 mL of viral transport media.
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āMinimum Volume Requested
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- Respiratory swab: 2ā3 mL of Universal or Viral Transport Medium
- Urine, unprocessed: 10-50 mL
- Urine, processed: Pellet resuspended in 2ā3 mL of Universal or Viral Transport Medium
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āTransport Medium (if using)
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For respiratory swabs only: 2ā3 mL of Universal or Viral Transport Medium
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āSpecimen Labeling
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āEach specimen tube must be labeled with at least two unique patient identifiers, e.g., patient full name and date of birth.
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āStorage & Preservation of Specimen / Shipping Conditions
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- For respiratory swabs or urine pellet, freeze or refrigerate specimens promptly after collection.
- For unprocessed urine, refrigerate specimens promptly after collection. Do not freeze unprocessed urine.
Ship refrigerated specimens to VRDL on cold packs. Ship frozen specimens to VRDL on dry ice.
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āShipping Instructions
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Work with your local public health department to ensure samples are packaged according to instructions for Biological Substance ā Category B (UN 3373) shipment.
Ship specimens and a hard copy of the completed submittal forms to:
CDPH VRDL
ATTN:
Specimen Receiving
850 Marina Bay Parkway
Richmond, CA 94804
Phone: 510-307-8585
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Turnaround Time
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3 Business Days
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Limitations
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āAdditional Information
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āThis test is intended for persons who received a measles-containing vaccine within the preceding 28 days and for whom there is concern of wildtype measles infection.
Specimens should be collected as close to rash onset as possible and preferably within 30 days after receipt of a measles-containing vaccine.
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āVRDL Points of Contact
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Medical and Epidemiology Liaisons: (510) 307-8585 or VRDL.submittal@cdph.ca.govāā
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