| Pre-Approval | Please submit the Hantavirus Submittal Instructions and Case Report Form (PDF) to VRDLās Medical and Epidemiology Liaisons at VRDL.Submittal@cdph.ca.gov for pre-approval.
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Supplemental Information Requested
| Contact VRDLās Medical and Epidemiology Liaisons at (510) 307-8585 or VRDL.Submittal@cdph.ca.gov for requested supplemental information, including but not limited to animal or environmental exposure, disease onset date, clinical symptoms
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Submittal Form
| Submit specimens accompanied with both: |
| Methodology (Commercial Test Name or Laboratory Developed Test (LDT)) | EIA: IgG and IgM (LDT/CDC)(Diagnostic)
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| Reflex Testing | TBD (see āAdditional Informationā below)
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| Acceptable Specimen Type(s) and Collection Method | Human specimens: - āSerum:
- āPlain Red-Top Tubes: Serum collected in plain, red-top tubes must be separated and transferred to sterile, screw-cap tubes for storage and transport.
- Serum Separator Tubes (SST): SST may be transported after centrifugation.
- āāPlasma: Plasma may be separated from (specify anticoagulant type) whole blood and transferred to sterile, screw-cap tubes for storage and transport.
- āāWhole blood: EDTA (lavender top) tubes
Additional specimens may be tested if patient is deceased (Surveillance Use Only) please contact VRDLās Medical and Epidemiology Liaisons at (510) 307-8585 or VRDL.Submittal@cdph.ca.gov for more information.ā |
| Minimum Volume Requested | - Serum: 1 mL
- Plasma: 1 mL
- Whole Blood in EDTA tubes: 5 mLā
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| Transport Medium (if using) | Not Applicable |
| Specimen Labeling | Each specimen tube must be labeled with at least two unique patient identifiers, e.g., patient full name and date of birth. |
| Storage & Preservation of Specimen / Shipping Conditions | - āSeparated Serum: Refrigerate or freeze separated serum promptly after collection.
- Serum Separator Tubes: Refrigerate, do not freeze.
- Plasma: Refrigerate or freeze separated plasma promptly after collection.
- Whole Blood: Refrigerate, do not freeze.
Ship refrigerated specimens to VRDL on cold packs. Ship frozen specimens to VRDL on dry ice.
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Shipping Instructions | Work with your local public health department to ensure samples are packaged according to instructions for Biological Substance ā Category B (UN 3373) shipment. Ship specimens and a hard copy of the completed submittal forms to: CDPH VRDL ATTN: Specimen Receiving 850 Marina Bay Parkway Richmond, CA 94804 Phone: 510-307-8585 |
| Turnaround Time | 10 Business Days |
| Limitations | Positive result does not confirm infection, clinical correlation is required. Negative result does not preclude the possibility of infection. Marginal values are likely to represent a patient in the early stages of a response or previously infected with a related, cross-reacting virus or noise in the system Bacterial or fungal contamination renders the specimen unsuitable for testing.
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| Additional Information | Since the incidence of HPS is rare in California, we recommend that you also submit a respiratory specimen for viral isolation and/or respiratory PCR assays to test for other agents that may be causing your patientās illness. Please contact VRDLās Medical and Epidemiology Liaisons at (510) 307-8585 for more information. This does not apply for submissions outside of California.
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| VRDL Points of Contact | Medical and Epidemiology Liaisons: (510) 307-8585 or VRDL.Submittal@cdph.ca.gov
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